Search Result
Results for "
fungal metabolite
" in MedChemExpress (MCE) Product Catalog:
3
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-111238
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- HY-P1703
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-
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- HY-N10186
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- HY-N10238
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- HY-125684
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- HY-N8548
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- HY-125705
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Herqueline A
|
Influenza Virus
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Infection
Cardiovascular Disease
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Herquline A (Herqueline A) is a fungal piperazine alkaloid. Herquline A is a fungal metabolite that inhibits platelet aggregation and replication of the influenza virus .
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-
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- HY-125344
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-
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- HY-118427
-
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Parasite
Endogenous Metabolite
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Infection
Cancer
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Asterriquinol D dimethyl ether is a fungal metabolite, which can inhibit mouse myeloma NS-1 cell lines with an IC50 of 28 μg/mL. Asterriquinol D dimethyl ether also inhibits Tritrichomonas foetus .
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-
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- HY-124551
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-
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- HY-N10234
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Acyltransferase
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Infection
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Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 0.8 μM .
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-
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- HY-N10270
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-
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- HY-N10220
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-
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- HY-136767
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Fungal
Antibiotic
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Infection
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Cladosporin is a fungal metabolite produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin completely inhibits growth of severa dermatophytes on agar medium at a concentration of 75 μg/mL .
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-
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- HY-125411
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Endogenous Metabolite
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Others
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Berninamycin D is a cyclic peptide fungal metabolite isolated from ermentation of Streptomyces bernensis .
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-
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- HY-121133
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Endogenous Metabolite
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Others
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(-)-Cyclopenol is a fungal metabolite isolated from an Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) .
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-
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- HY-W145584
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- HY-N8396
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- HY-125060
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- HY-126603
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Others
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Infection
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Asperlactone has anti-inflammatory activity. Asperlactone inhibits superoxide anion generation. Asperlactone is a fungal metabolite that can be isolated from isolated from Aspergillus ochraceus .
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-
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- HY-135154
-
|
GABA Receptor
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Neurological Disease
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epi-Aszonalenin A is a benzodiazepine fungal metabolite originally isolated from Aspergillus novofumigatus. epi-Aszonalenin A can be used as a psychoactive agent .
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- HY-N8349
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Parasite
Endogenous Metabolite
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Infection
Cancer
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19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .
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- HY-N8385
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Parasite
Endogenous Metabolite
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Infection
Cancer
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19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity .
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- HY-N10194
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Parasite
Endogenous Metabolite
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Infection
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P-orlandin, a fungal metabolite, prevents FREP1 from binding to gametocytes or ookinetes. P-orlandin effectively inhibits P. falciparum infection in mosquitoes .
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-
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- HY-N10228
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Endogenous Metabolite
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Infection
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Gliorosein is a fungal metabolite isolated from Gliocladium. Gliorosein is isomeric with the quinol but shows a different ultraviolet absorption spectrum .
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- HY-N10190
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Parasite
Endogenous Metabolite
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Infection
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Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC50 of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC50 of 3 µM, and it is nontoxic to human cells .
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- HY-N10227
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- HY-114646
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Endogenous Metabolite
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Cancer
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TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter .
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- HY-125170
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STAT
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Cancer
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Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer .
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- HY-N10192
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Endogenous Metabolite
Bacterial
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Infection
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Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .
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- HY-P3107
-
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Endogenous Metabolite
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Inflammation/Immunology
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Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC50 value of 0.86 μM .
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- HY-136901
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FC-101
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Reactive Oxygen Species
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Cardiovascular Disease
Cancer
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Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity . Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS) .
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- HY-119552
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LL-S490β
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Endogenous Metabolite
Neurokinin Receptor
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Neurological Disease
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Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ 3H]-SP binding to human astrocytoma cells with a Ki of 170 μM .
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- HY-N10322
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Drug Metabolite
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Others
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2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. Emodin is an anthraquinone present in fungal metabolites and constituent of rhubarb. 2-Hydroxyemodin proves to be mutagenic to Salmonella typhimurium TA1537 in the absence of activation system .
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- HY-120607
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Parasite
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Infection
Cancer
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Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC50 value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines .
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- HY-126989
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Arp2/3 Complex
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Cancer
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19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .
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- HY-W099579
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Kojic dipalmitate
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Tyrosinase
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Endocrinology
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Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .
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- HY-163113
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Others
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Cancer
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Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .
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- HY-N6798
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Thermozymocidin; ISP-I
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HCV
Antibiotic
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Infection
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Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 µg/mL for inhibiting HCV infection .
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- HY-120733
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FKI-4905
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Bacterial
Endogenous Metabolite
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Infection
Inflammation/Immunology
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Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .
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- HY-129319
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- HY-117713
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- HY-N10282
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- HY-N6217
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- HY-N10257
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- HY-119328
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- HY-116290
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Squalestatin S1
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Others
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Others
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Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase .
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- HY-129515
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Fungal
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Others
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Trichodecenin II is a fungal metabolite that can be found in conidia of the fungus, Trichoderma viride .
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- HY-130214
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-
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- HY-118100
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Cyclo(L-Tyr-L-Val)
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Drug Metabolite
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Others
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Cyclo(Tyr-Val) (Cyclo(L-Tyr-L-Val)) is a diketopiperazine secondary fungal metabolite originally isolated from N. gilva.
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- HY-N7731
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Others
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Others
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(±)-Lavandulol is an irregular monoterpene alcohol. (±)-Lavandulol can be transformed by a fungal strain Rhizopus oryzae into corresponding oxygenated metabolite .
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- HY-142908
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Endogenous Metabolite
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Cancer
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Maximiscin, a fungal metabolite, induces DNA damage and shows selective cytotoxic activity against a subtype of triple-negative breast cancer.
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- HY-N10261
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- HY-153671
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Others
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Infection
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4'-Methyl-β-naphthoflavone is a metabolite of Naphthoflavones (benzoflavones) in fungal. Naphthoflavones are activators or inhibitors of CYP-450 .
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- HY-N7291
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Others
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Others
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Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939 .
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- HY-103382
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Fungal
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Infection
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Arcyriaflavin A is a fungal metabolite obtained from the fungi, Nocardiopsis. Arcyriaflavin A is an inhibitor of CDK4 (IC50 = 140 nM) and CaMKII (IC50 = 25 nM) .
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- HY-N10262
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Endogenous Metabolite
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Others
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Piliformic acid is a fungal metabolite found in the endophytic fungus Xylariasp sp.(No. 2508) from mangrove trees from the coast of the South China Sea .
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- HY-125319
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Acyltransferase
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Metabolic Disease
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Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .
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- HY-W596782
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Chaetochromin
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Others
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Neurological Disease
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Chaetochromin A (Compound 1) is a fungal metabolite. Chaetochromin A shows inhibitory effect on botulinum neurotoxin serotype A (BoNT A) (IC50= 24.6 μM) .
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- HY-N8400
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Endogenous Metabolite
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Others
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Roridin L2, a fungal metabolite, is a biosynthetic precursor of Satratoxin G. Roridin L2 possesses little in vitro or in vivo toxic activity .
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- HY-129295
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Acyltransferase
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Metabolic Disease
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Amidepsine D is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .
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- HY-N6781
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Phosphodiesterase (PDE)
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Infection
Cancer
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Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC50 value of 9 μM. Ophiobolin A antimicrobial and anticancer activity .
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- HY-121532
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Ras
Apoptosis
Autophagy
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Cancer
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(-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line) .
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- HY-137801
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Parasite
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Infection
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Sesquicillin A is an insecticidal antibiotic, a fungal metabolite isolated from white plantain. Sesquicillin A inhibits the growth of A. salina brine shrimp with the MIC value of 6.25 µg/mL .
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- HY-N8846
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Fungal
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Infection
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dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .
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- HY-N6770
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(S)-Curvularin
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NO Synthase
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Infection
Inflammation/Immunology
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Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM .
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- HY-P2228
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HDAC
Apoptosis
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Cancer
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Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3 .
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- HY-133154
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CAIR; 4-Carboxy-AIR
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Endogenous Metabolite
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Infection
|
Carboxyaminoimidazole ribotide (CAIR) is a metabolite of E. coli. Carboxyaminoimidazole ribotide can be used to detect distinctive features of E. coli PurE active site and synthesis fungal de novo purine .
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- HY-111321
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- HY-137989A
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Voriconazole oxynitride hydrochloride
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Drug Metabolite
|
Infection
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Voriconazole N-oxide (Voriconazole oxynitride) (hydrochloride) is the main metabolite of Voriconazole (HY-76200) , a widely used triazole antibiotic (fungal). Voriconazole N-oxide (hydrochloride) provides information on the patient's drug metabolism capacity .
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- HY-N10265
-
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Endogenous Metabolite
|
Cancer
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Stephacidin B is a fungal metabolite. Stephacidin B shows in vitro cytotoxicity against a panel of human tumor cell lines. Stephacidin B shows the strongest cytotoxicity against testosterone-dependent prostate LNCaP cancer cells .
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- HY-125706
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- HY-N6772
-
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Autophagy
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Cancer
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Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation .
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- HY-W145584S
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- HY-N8285
-
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Parasite
|
Infection
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Sporogen AO-1 is a fungal metabolite originally isolated from the fungusAspergillus oryzae. Sporogen AO-1 has significant antimalarial activity againstplasmodium falciparum, with an IC50 value of 1.53 μM, and also has certain cytotoxicity .
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- HY-N6697
-
|
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops .
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- HY-N6735
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OSI 2040
|
|
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Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research .
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- HY-146190
-
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Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Callophycin A, a red seaweed derived metabolite, possessing potent activity against Candida albicans with MIC of 62.5~250 mg/L. Callophycin A significantly reduces fungal burden of vaginal candidiasis induced mice, also decreases inflammatory response and immune molecules .
|
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- HY-116700
-
|
HIV Protease
HIV
|
Infection
|
Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum .
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-
- HY-129578
-
-
- HY-121004
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Lycopersin
|
Fungal
Antibiotic
|
Infection
|
Bikaverin (Lycopersin) is a reddish pigment produced by different fungal species. Bikaverin shows antibiotic properties against certain protozoa and fungi .
|
-
- HY-N10205
-
|
Endogenous Metabolite
|
Cancer
|
Rostratin C, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 value of 0.76μg /mL .
|
-
- HY-121184
-
-
- HY-N6027
-
|
Fungal
Bacterial
|
Infection
|
Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. Cyclosporin C is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs=0.1-5 μg/ml).
|
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- HY-100618
-
-
- HY-N6801
-
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Caspase
Bacterial
Apoptosis
Antibiotic
|
Infection
Inflammation/Immunology
|
Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .
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-
- HY-N8472
-
|
GABA Receptor
|
Infection
|
Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on B. mori GABAR RDL with an IC50 of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50 of 1.66 nM. Chrodrimanin B, a meroterpenoid, shows insecticidal activity .
|
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- HY-N10196
-
-
- HY-N6697S
-
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Isotope-Labeled Compounds
|
Cancer
|
Aflatoxin G1- 13C17 is the 13C labeled Aflatoxin G1 (HY-N6697) . Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops .
|
-
- HY-N6801S
-
|
Isotope-Labeled Compounds
|
Infection
|
Nivalenol- 13C15 is the 13C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .
|
-
- HY-N11642
-
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Others
|
Others
|
Ganodermacetal is a highly oxidized lanostane triterpene, that can be isolated from G. amboinense. Ganodermacetal shows a marked toxicity to brine shrimp larvae .
|
-
- HY-113205
-
15-keto-PGE2
|
Endogenous Metabolite
Prostaglandin Receptor
STAT
PPAR
|
Cancer
|
15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth .
|
-
-
-
HY-L0117V
-
|
1,412 compounds
|
Glycomimetics are designed to mimic the structure of natural carbohydrates and modulate their disease-related functions. Macrocyclic glycomimetics are an extremely interesting class of glycomimetics as they occupy space between small and macro molecules. Macrocyclic glycomimetics are mostly represented by naturally occurring molecules derived from marine microorganisms and bacterial or fungal metabolites.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P3107
-
|
Endogenous Metabolite
|
Inflammation/Immunology
|
Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC50 value of 0.86 μM .
|
-
- HY-P2228
-
|
HDAC
Apoptosis
|
Cancer
|
Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3 .
|
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W145584S
-
|
D-Iditol- 13C is the 13C labeled D-Iditol. D-Iditol is a fungal metabolite, a sugar alcohol that accumulates in galactokinase deficiency. D-Iditol may have potential antitumour activity[1][2][3].
|
-
-
- HY-N6697S
-
|
Aflatoxin G1- 13C17 is the 13C labeled Aflatoxin G1 (HY-N6697) . Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops .
|
-
-
- HY-N6801S
-
|
Nivalenol- 13C15 is the 13C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .
|
-
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